Experienced former England striker Kevin Davies is available again after serving a three-match suspension for a red card incurred before the first meeting of the Reds and PNE, a goalless draw at the City Ground.
New loan signing Craig Davies from Bolton is cup-tied, however.
Manager Simon Grayson feels his side are still the underdogs in the tie despite now having home advantage.
He told his club's official website: "Who knows what team they will put out, but we know they are a strong, powerful unit who will be a tough game for us."
Update - In what Billy Davies describes as a 'huge blow' for Forest, midfielder David Vaughan could be out for three months after sustaining a knee injury.